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SLNP-IC1

SLNP-IC1
Solid Lipid Nanoparticle (SLNP) Nammisome formulated with Doxorubicin Prodrug (IC1) 

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  • Why a Doxorubicin Prodrug? Doxorubicin is a widely used immunogenic cell death (ICD) inducing chemotherapeutic drug.  Doxil, the liposome-encapsulated form of Doxorubicin, shows superiority to free Doxorubicin clinical performance in a variety of neoplastic conditions but still faces challenges.  SLNP-IC1 is a novel Prodrug of Doxorubicin formulated as an SLNP, with an improved therapeutic window in preclinical studies and an easier, more reproducible manufacturing process than Doxil. â€‹

  • Target Indications: Liposomal Doxorubicin has been approved in the US for ovarian (disease progression/recurrence after platinum-based chemo), Kaposi’s sarcoma (after the failure of prior systemic chemo or intolerance to it), and multiple myeloma (in combination with bortezomib).  SLNP-IC1 may therefore be applicable to these indications, and potentially to other solid tumors as well.

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SLNP-IC1
Demonstrated Improved Stability, Efficacy, and Safety vs. Doxil

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Improved Stability 

Solid Lipid Nanoparticle formulated IC1 Prodrug dramatically reduces release of free Doxorubicin in human serum compared to liposomal Doxorubicin (LNP-DOX)

Enhanced Efficacy

Tumor growth inhibition at equivalent dose in vivo (EMT-6 breast cancer murine tumor model) presumably due to enhanced exposure of the nanocarrier associated Doxorubicin

Improved Safety

At a significantly higher dose of 12 mg/kg of Doxorubicin equivalents, mice treated with the Nammisome-formulated Doxorubicin exhibit less body weight loss, indicating reduced toxicity

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